Contributing Scientist
Stefan Laufer
Pharmazeutische Chemie, Pharmazeutisches Institut, Eberhard-Karls-Universität Tübingen
- Contribution: CADD: Structure-based design, database-mining Synthesis: Hit-Lead-Candidate: MedChem, Resin-based Parallel synthesis Primary screen: Enzyme assays, cell-based assays, humane whole blood based assays In vitro metabolism: Isolated CYPs, Liver microsomes, Liver homogenate (rat and human) Metabolic stability: human whole blood, liver homogenate
- Research interest: Targets: Proteinkinases p38α and δ, JNK3, JAK3, EGFR- mt/mutants GSK3ß, Aurora Activating Protein, MKKs mPGES1, LOXs PI3Kγ
- Expertise: „Proof of concept“ up to Phase IIa
- Equipment: IR, NMR, GC-MS, LC-MS (Ion trap, Triple Quad), Maldi-TOF