Screening@FMP: Publications
- Fetz V, Knauer SK, von Kries JP & Stauber RH. Translocation biosensors- Cellular system integrators to dissect nuclear export by Chemicogenomics. Sensors 2009, in press
- Podust, LM, Ouellet, H, von Kries, JP, de Montellano, PO. Interaction of mycobacterium tuberculosis CYP130 with heterocyclic arylamines. Journal of Biological Chemistry, 2009, accepted
- Konkle, ME, Hargrove, TY, Kleshchenko, YY, von Kries, JP, Ridenour, W, Uddin, MdJ, Caprioli, RM, Marnett, LJ, Nes, WD, Villalta, F, Waterman, MR and Lepesheva, GI. Indomethacin Amides as a Novel Molecular Scaffold for Targeting Trypanosoma cruzi Sterol 14α-Demethylase. Journal of Medicinal Chemistry, 2009, accepted
- Nasser Eddine A, von Kries JP, Podust MV, Warrier T, Kaufmann SH, Podust LM. X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha -demethylase (CYP51). J Biol Chem. 2008 Mar 26, doi:10.1074/jbc.M801145200
- Hellmuth K, Grosskopf S, Lum CT, Würtele M, Röder N, von Kries JP, Rosario M, Rademann J and Birchmeier W. Specific Inhibitors of the Protein Tyrosine Phosphatase Shp2 Identified by High-throughput Docking. PNAS 2008, accepted
- Schmidt MF, Isidro-Llobet A, Lisurek M, El-Dahshan A, Tan J, Hilgenfeld R, Rademann J. Sensitized Detection of Inhibitory Fragments and Iterative Development of Non-Peptidic Protease Inhibitors by Dynamic Ligation Screening. Angew Chem 2008, 10.1002/anie.200704594
- Podust LM, von Kries JP, Eddine AN, Kim Y, Yermalitskaya LV, Kuehne R, Ouellet H, Warrier T, Alteköster M, Lee JS, Rademann J, Oschkinat H, Kaufmann SH, Waterman MR. Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography. Antimicrob Agents Chemother. 2007 Nov;51(11):3915-23.
- Lygren B, Carlson CR, Santamaria K, Lissandron V, McSorley T, Litzenberg J, Lorenz D, Wiesner B, Rosenthal W, Zaccolo M, Taskén K, Klussmann E. AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. EMBO Rep. 2007 Nov;8(11):1061-7.
- Al-Gharabli SI , Ali Shah ST, Weik S, Schmidt M, Mesters JR, Kuhn D, Klebe G, Hilgenfeld R, Rademann J. An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors. ChemBioChem 2006, 7, 1048-1055. ·
- Joshi M, Vargas C, Boisguerin P, Diehl A, Krause G, Schmieder P, Moelling K, Hagen V, Schade M, Oschkinat H. Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3790-5. ·
- Mueller-Dieckmann C, Kernstock S, Lisurek M, von Kries JP, Haag F, Weiss MS, Koch-Nolte F. The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15026-31.
- Eswaran J, von Kries JP, Marsden B, Longman E, Debreczeni JE, Ugochukwu E, Turnbull A, Lee WH, Knapp S, Barr AJ. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochem J. 2006 May 1;395(3):483-91. ·
- Manger M, Scheck M, Prinz H, von Kries JP, Langer T, Saxena K, Schwalbe H, Fürstner A, Rademann J, Waldmann H. Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach. Chembiochem. 2005 Oct;6(10):1749-53. ·
- Singh RK, Kefala G, Janowski R, Mueller-Dieckmann C, von Kries JP, Weiss MS. The high-resolution Structure of LeuB (Rv2995c) from Mycobacterium tuberculosis. J Mol Biol. 2005 Feb 11;346(1):1-11.
- von Kries JP, Winbeck G, Asbrand C, Schwarz-Romond T, Sochnikova N, Dell'Oro A, Behrens J, Birchmeier W. Hot spots in beta-catenin for interactions with LEF-1, conductin and APC. Nat Struct Biol. 2000 Sep;7(9):800-7.
